Stain removing? I have a stain on one of my shirts that I NEED...

I have a stain on one of my shirts that I NEED to take out. Please help!? I enjoy already washed it worth I alredy dried it and I've been wash it over and over! Any suggestions?
Answers:    Need more information....what is the stain from? Is like a grease or grease stain (looks like a damp spot that doesn't ever dry)?
besides needing to know the material content and staining material, don't ever dry something where on earth the stain remains. Many times, this will permanently set the stain.